Purpose: To evaluate a therapeutic monitoring strategy for ectopic pregnancies treated with methotrexate (MTX) injection based on hCG level kinetics, in order to identify patients at low risk of treatment failure. Materials and Methods: This series of 14 cases allowed us to evaluate the success rate of therapeutic management with a single injection of methotrexate (MTX), based on the kinetics of hCG levels. The protocol stipulated that if the decrease was greater than 20% between days 1 and 4, follow-up was limited to an hCG measurement one month later. Results: Among the 14 patients treated, the overall success rate of MTX treatment was 85.71%. Conclusion: Our protocol allows us to select patients at low risk of failure of single-dose MTX treatment, and to offer them less restrictive monitoring.
Cite this paper
Senouci, O. E. S. , Aboubekr, F. , Bedjaoui, H. , Messaoud, M. and Tachema, I. (2026). Correlation between hCG Kinetics and the Effectiveness of Methotrexate in the Management of Ectopic Pregnancies. Open Access Library Journal, 13, e14676. doi: http://dx.doi.org/10.4236/oalib.1114676.
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