Primary tumors of the vagina are extremely rare, accounting for less than 2% of gynecological neoplasms. Among these, mixed tumors with both epithelial and mesenchymal components are exceptional and rarely described in the literature. We report the case of a 50-year-old female patient with a mixed tumor of the vagina, which required multidisciplinary management. Through this observation, we discuss the clinical, radiological, and histopathological features of this rare entity, as well as the available treatment options.
Cite this paper
Mahfoudi, A. E. , Elmaazouzi, S. , Fakhir, B. , Harrou, K. , Boukhanni, L. , Asmouki, H. , Soummani, A. , Elkhadraoui, H. and Rais, H. (2026). Mixed Tumor of the Vagina (MTV): A Rare Case Report. Open Access Library Journal, 13, e15153. doi: http://dx.doi.org/10.4236/oalib.1115153.
Oliva, E., Gonzalez, L., Dionigi, A. and Young, R.H. (2004) Mixed Tumors of the Vagina: An Immunohistochemical Study of 13 Cases with Emphasis on the Cell of Origin and Potential Aid in Differential Diagnosis. Modern Pathology, 17, 1243-1250. https://doi.org/10.1038/modpathol.3800173
Song, Y., Wu, S.G., Dong, S.N., Luo, F. and Liu, K.P. (2017) Benign Mixed Tumor of the Vagina. European Journal of Gynaecological Oncology, 38, 465-468.
Sirota, R.L., Dickersin, G.R. and Scully, R.E. (1981) Mixed Tumors of the Vagina. A Clinico-pathological Analysis of Eight Cases. The American Journal of Surgical Patholo-gy, 5, 413-422. https://doi.org/10.1097/00000478-198107000-00001
Tang, X., Xu, Y., Yao, L., Yuan, L. and Huang, Y. (2025) Spindle Cell Epithelioma of the Vagina with Rare Morphology: A Case Report and Literature Review. Frontiers in On-cology, 15, Article 1551607. https://doi.org/10.3389/fonc.2025.1551607
Murdoch, F., Sharma, R. and Al-Nafussi, A. (2003) Benign Mixed Tumor of the Vagina: Case Report with Expanded Immunohistochemical Profile. International Journal of Gynecological Cancer, 13, 543-547. https://doi.org/10.1046/j.1525-1438.2003.13309.x
Kang, M.S. and Yoon, H.K. (2002) Mixed Tumor of the Vagina: A Case Report. Journal of Kore-an Medical Science, 17, 845-848. https://doi.org/10.3346/jkms.2002.17.6.845
WHO Classification of Tu-mours Editorial Board (2020) Mesenchymal Tumours of the Lower Genital Tract. In: WHO Classification of Tumours, Eds., Female Genital Tmours (5th Edi-tion), World Health Organization, 414 p.
Laspas, F., Roussakis, A., Papa-dopoulos, S., Fanariotis, I., Kritikos, N. and Kehagias, D. (2010) Mixed Tumor of the Vagina: Sonographic and Magnetic Resonance Imaging Findings. Ultrasound in Obstetrics & Gynecology, 35, 617-619. https://doi.org/10.1002/uog.7511
Pulappadi, V.P., Manchanda, S., Dhamija, E. and Jana, M. (2023) Multimodality Imaging of Diseases of the Vagina. British Journal of Radiology, 97, 513-525. https://doi.org/10.1093/bjr/tqad052