Background: Malaria is a disease of global health concern; however, it has even a greater impact on people in Sub-Saharan Africa, of which Nigeria is a part. Pregnant women and those who are immunocompromised are more susceptible to malaria and these groups may show life-threatening symptoms, which have led to the recommendation of intermittent preventive treatment for malaria in pregnancy. In spite of this, the prevalence of malaria in pregnant women has remained high, thus the need to study the uptake of IPTp. Objective: To determine the uptake of IPTp-SP and its prevention of malaria in pregnancy. Methods: This is a cross-sectional study to determine the uptake of intermittent preventive treatment of malaria using sulfonamide-pyrimethamine and its prevention of malaria in pregnancy at Alex Ekwueme Federal University Teaching Hospital, Abakaliki, Ebonyi State. Results were presented in numbers and percentages, and Pearson’s correlation and Spearman’s correlation were used to analyse the relationship between the number of doses of IPTp-SP and malaria in pregnancy. A p-value of ≤0.05 was taken to be statistically significant. Results: Thirty-five women (19.0%) reported using Artemisinin-based Combination Therapy (ACT), and 8 (4.3%) could not recall the drug used for their treatment of malaria. About half of the respondents (93; 50.5%) received four doses, while 39 (21.2%) received five doses. Among those who received four doses of IPTp, 78 respondents had no malaria treatment, while among those with five doses, 36 had no malaria treatment. Whereas majority of those who had lower than 2 doses of SP had more treatments for malaria. The study showed a negative correlation between IPTp-SP dose and frequency of malaria treatment (Pearson r = −0.351, Spearman ρ = −0.373; p < 0.001). Conclusion: Most of the women took more than 3 doses of IPTp and those who had malaria had treatment with ACT. Increased doses of IPTp in pregnancy are vital in the prevention of malaria in pregnancy.
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Nweke, A. N. , Ndukwe, O. E. , Omovoh, I. C. U. , Ikegbu, M. , Obi, C. N. , Mbanefo, O. C. and Onuchukwu, V. U. J. (2025). Uptake of Intermittent Preventive Treatment for Malaria and Treatment of Malaria in Pregnancy at a Tertiary Hospital. Open Access Library Journal, 12, e14517. doi: http://dx.doi.org/10.4236/oalib.1114517.
Dawaki, S., Al-Mekhlafi, H.M., Ithoi, I., Ibrahim, J., Atroosh, W.M., Abdulsalam, A.M., et al. (2016) Is Nigeria Winning the Battle against Malaria? Prevalence, Risk Factors and KAP Assessment among Hausa Communities in Kano State. Malaria Journal, 15, Article No. 351. https://doi.org/10.1186/s12936-016-1394-3
Nwonwu, E.U., Ibekwe, P.C., Ugwu, J.I., Obarezi, H.C. and Nwagbara, O.C. (2009) Prevalence of Malaria Parasitemia and Malaria Related Anaemia among Pregnant Women in Abakaliki, South East Nigeria. Nigerian Journal of Clinical Practice, 12, 182-186.
Piñeros, J.G., Tobon-Castaño, A., álvarez, G., Portilla, C. and Blair, S. (2013) Maternal Clinical Findings in Malaria in Pregnancy in a Region of Northwestern Colombia. The American Society of Tropical Medicine and Hy-giene, 89, 520-526. https://doi.org/10.4269/ajtmh.12-0205
Desai, M., Hill, J., Fernandes, S., Walker, P., Pell, C., Gutman, J., et al. (2018) Prevention of Malaria in Pregnancy. The Lancet Infectious Diseases, 18, e119-e132. https://doi.org/10.1016/s1473-3099(18)30064-1
Bello, O.O. and Oni, O. (2020) Health Workers’ Awareness and Knowledge of Current Recommendation of Intermittent Pre-ventive Treatment in Pregnancy in South-Western Nigeria. Ethiopian Journal of Health Sciences, 30, 125-134. https://doi.org/10.4314/ejhs.v30i1.16
Pourhoseingholi, M.A., Vahedi, M. and Rahimzadeh, M. (2013) Sample Size Calculation in Medical Studies. Gas-troenterology and Hepatology from Bed to Bench, 6, 14-17.
Kalu, G.O., Francis, J.M., Ibisomi, L., Chirwa, T. and Kagura, J. (2023) Factors Associated with the Uptake of Intermittent Preventive Treatment (IPTp-SP) for Malaria in Pregnancy: Further Analysis of the 2018 Nigeria Demographic and Health Sur-vey. PLOS Global Public Health, 3, e0000771. https://doi.org/10.1371/journal.pgph.0000771
Fokam, E.B., Ngimuh, L., Anchang-Kimbi, J.K. and Wanji, S. (2016) Assessment of the Usage and Effec-tiveness of Intermittent Preventive Treatment and Insecticide-Treated Nets on the Indicators of Malaria among Pregnant Women Attending Antenatal Care in the Buea Health District, Cameroon. Malaria Journal, 15, Article No. 172. https://doi.org/10.1186/s12936-016-1228-3
Ahadzie-Soglie, A., Ad-dai-Mensah, O., Abaka-Yawson, A., Setroame, A.M. and Kwadzokpui, P.K. (2022) Prevalence and Risk Factors of Malaria and Anaemia and the Impact of Preventive Methods among Pregnant Women: A Case Study at the Akatsi South District in Ghana. PLOS ONE, 17, e0271211. https://doi.org/10.1371/journal.pone.0271211
Bello, F.A. and Ayede, A.I. (2019) Prevalence of Malaria Parasitaemia and the Use of Malaria Preven-tion Measures in Pregnant Women in Ibadan, Nigeria. Annals of Ibadan Post-graduate Medicine, 17, 124-129.
Apinjoh, T.O., Ntui, V.N., Chi, H.F., Mo-yeh, M.N., Toussi, C.T., Mayaba, J.M., et al. (2022) Intermittent Preventive Treatment with Sulphadoxine-Pyrimethamine (IPTp-SP) Is Associated with Protection against Sub-Microscopic P. falciparum Infection in Pregnant Women during the Low Transmission Dry Season in Southwestern Cameroon: A Semi-Longitudinal Study. PLOS ONE, 17, e0275370. https://doi.org/10.1371/journal.pone.0275370
Omidiji, M.O., Lesi, F.E.A., Esezobor, C.I., Fajolu, I.B., Oyibo, W.A. and Daramola, A. (2025) Preva-lence of Congenital Malaria in an Urban and a Semirural Area in Lagos: A Two-Centre Cross-Sectional Study. Scientific Reports, 15, Article No. 10709. https://doi.org/10.1038/s41598-025-94800-w
Newton, S.K., Annor, R.B. and Owusu-Dabo, E. (2020) The Effectiveness of the Revised Intermittent Preventive Treatment with Sulphadoxine Pyrimethamine (IPTp-SP) in the Northern Ghana. Journal of Tropical Medicine, 20, 1-9.
Miatu, A.N., Cheriro, B.R. and Kamija, S.P. (2024) Prevalence and Health System Determi-nants of Uptake of Three or More Doses of Sulphadoxine Pyrimethamine for Intermittent Preventive Treatment of Malaria during Pregnancy. East African Medical Journal, 101, 7552-7562.
Nana, R.R.D., Hawadak, J., Foko, L.P.K., Kumar, A., Chaudhry, S., Arya, A., et al. (2022) Intermittent Preventive Treat-ment with Sulfadoxine Pyrimethamine for Malaria: A Global Overview and Challenges Affecting Optimal Drug Uptake in Pregnant Women. Pathogens and Global Health, 117, 462-475. https://doi.org/10.1080/20477724.2022.2128563
Mbassi, D.E., Pfaffendorf, C., Mombo-Ngoma, G., Kreuels, B. and Ramharter, M. (2023) Re-al-Life Effectiveness of Anti-Malarial Treatment Regimens: What Are We Aiming for? Malaria Journal, 22, Article No. 189. https://doi.org/10.1186/s12936-023-04606-2
Maafoh, C. and Onyed-ibe, K. (2024) Alternative First-Line Malaria Treatment. Annals of African Medicine, 23, 5-12. https://doi.org/10.4103/aam.aam_35_23
Mutanyi, J.A., Onguru, D.O., Ogolla, S.O. and Adipo, L.B. (2021) Determinants of the Up-take of Intermittent Preventive Treatment of Malaria in Pregnancy with Sul-phadoxine Pyrimethamine in Sabatia Sub County, Western Kenya. Infectious Diseases of Poverty, 10, Article No. 106. https://doi.org/10.1186/s40249-021-00887-4
Boateng, I.O. and Anto, F. (2017) Intermittent Preventive Treatment of Malaria in Pregnancy: A Cross-Sectional Survey to Assess Uptake of the New Sulfadox-ine—Pyrimethamine Five Dose Policy in Ghana. Malaria Journal, 16, Article No. 323.
