Background: The association of seminoma with malignant hypercalcemia is extremely rare. Case findings: We present a 32-year-old male with hypercalcemia. Subsequently, a metastatic seminoma was discovered according to computed tomography and biopsy testing. Elevated 1,25-dihydroxyvitamin D levels were identified as the cause of hypercalcemia. Conclusion: Hypercalcemia is a rare but possible scenario in seminoma and therefore it is important to consider this uncommon cause in the differential diagnosis.
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Kreze, A. , Klemperová, K. , Vu, Q. , š, Z. , pů, rková, Balá, L. , ž, ová, Kuchař, O. , Kolesá, J. J. and r (2025). Hypercalcemia in a Seminoma. Open Access Library Journal, 12, e14041. doi: http://dx.doi.org/10.4236/oalib.1114041.
Asonitis, N., Angelousi, A., Zafeiris, C., Lambrou, G.I., Dontas, I. and Kassi, E. (2019) Diagnosis, Pathophysiology and Management of Hypercalcemia in Ma-lignancy: A Review of the Literature. Hormone and Metabolic Research, 51, 770-778. https://doi.org/10.1055/a-1049-0647
Simha, V., Shree, M.S., Velukur, S.V. and Srivatsa, N. (2023) Paraneoplastic Hypercalcaemia as a Cause of Unexplained Renal Impairment in a Patient with Seminoma: A Case Report. European Medical Journal Urology, 4, 71-75. https://doi.org/10.33590/emjurol/10302136
Chakhtoura, M. and El-Hajj Fuleihan, G. (2021) Treatment of Hypercalcemia of Malignancy. Endo-crinology and Metabolism Clinics of North America, 50, 781-792. https://doi.org/10.1016/j.ecl.2021.08.002
Zagzag, J., Hu, M.I., Fisher, S.B. and Perrier, N.D. (2018) Hypercalcemia and Cancer: Differential Diagnosis and Treatment. CA: A Cancer Journal for Clinicians, 68, 377-386. https://doi.org/10.3322/caac.21489
Yunita, B. and Cahyanur, R. (2023) Pathophysiology and Management of Hypercalcemia in Malignancy. Asian Jour-nal of Oncology, 9, Article No. 12. https://doi.org/10.25259/asjo-2022-27-(371)
Naous, E., Jain, A., ElNajjar, M. and Sabet, A. (2024) 7082 Hypercalcemia Due to Tumoral Produc-tion of Calcitriol by Seminoma in a Patient with Pre-Existing Primary Hy-perparathyroidism. Journal of the Endocrine Society, 8, bvae163.429. https://doi.org/10.1210/jendso/bvae163.429
Grote, T.H. and Hainsword, J.D. (1987) Hypercalcemia and Elevated Serum Calcitriol in a Pa-tient with Seminoma. Archives of Internal Medicine, 147, 2212-2213. https://doi.org/10.1001/archinte.1987.00370120148027
Hewison, M., Burke, F., Evans, K.N., Lammas, D.A., Sansom, D.M., Liu, P., et al. (2007) Ex-tra-Renal 25-Hydroxyvitamin D3-1α-Hydroxylase in Human Health and Disease. The Journal of Steroid Biochemistry and Molecular Biology, 103, 316-321. https://doi.org/10.1016/j.jsbmb.2006.12.078
Evans, K.N., Taylor, H., Zehnder, D., Kilby, M.D., Bulmer, J.N., Shah, F., et al. (2004) Increased Expres-sion of 25-Hydroxyvitamin D-1α-Hydroxylase in Dysgerminomas: A Novel form of Humoral Hypercalcemia of Malignancy. The American Journal of Pathology, 165, 807-813. https://doi.org/10.1016/s0002-9440(10)63343-3
Hara, N., Suwanai, H., Abe, H., Yakou, F., Ishikawa, T., Urayama, M., et al. (2022) Hy-percalcemia Associated with Dysgerminoma and Elevation of Calcitriol: A Case Report and Review of the Literature. SAGE Open Medical Case Reports, 10, 1-6. https://doi.org/10.1177/2050313x211068562
da Silva, M.A.P., Ed-mondson, J.W., Eby, C. and Loehrer, P.J. (1992) Humoral Hypercalcemia in Seminomas. Medical and Pediatric Oncology, 20, 38-41. https://doi.org/10.1002/mpo.2950200108
Aggarwal, G., Gupta, S. and Khwaunju, P. (2022) Hypercalcemia in Urological Malignancies: A Review. Türk üroloji Dergisi/Turkish Journal of Urology, 48, 243-253. https://doi.org/10.5152/tud.2022.22006
Paris, E., Fugaccia, C., Hendry, D., Findlay, M. and White, J. (2022) Hypercalcaemia and Acute Kidney Injury: A Rare Presentation of Seminoma. Journal of the Royal College of Physicians of Ed-inburgh, 52, 138-141. https://doi.org/10.1177/14782715221103661
Sim, J., Irvin, J. and Al-torok, N. (2025) 1,25-Dihydroxyvitamin D Mediated Hypercalcemia in Semi-noma. The American Journal of the Medical Sciences, 369, 292-295. https://doi.org/10.1016/j.amjms.2024.08.015