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骨桥蛋白配体及其与心血管疾病关系研究进展
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Abstract:
骨桥蛋白(OPN)是由骨桥蛋白基因(SPP1)编码的主要参与多种细胞功能的配体蛋白，是一种带负电的，非胶原性骨基质糖蛋白的，多数在细胞外基质(ECM)中发挥作用的一类重要的配体蛋白分子。OPN由胎盘等多种组织表达，含有信号肽、精氨酸–甘氨酸–天冬氨酸(Arg-Gly-Asp, RGD)、糖基化位点和肝素结合域等多种功能序列的转化相关性磷酸蛋白。多项研究证明OPN具有细胞粘附、细胞募集、细胞因子表达、信号转导、肿瘤发生和转移、细胞免疫、加速血管生成和纤维化等多种生物学功能，成为研究的热点，有意义的分子靶点不断被识别，逐渐成为疾病诊断和治疗的新靶标，本文对近年来OPN与心血管疾病的关系作简要综述。
Osteopontin (OPN) is a negatively charged, non-collagenous bone matrix glycoprotein mainly in various cellular functions as a ligand protein. It is expressed in various tissues including placenta, and contains a signal peptide, arginine-glycinepartic acid (Arg-Gly-Asp, RGD), glycosylation sites, and heparin binding domains, among other functional sequences, as transforming-related acidic phosphoprotein. Numerous studies have shown that OPN has various biological functions such as cell adhesion, cell recruitment, cytokine expression, signalduction, tumorigenesis and metastasis, cellular immunity, angiogenesis, and fibrosis, making it a hot topic in research. Meaningful molecular targets continuously being identified, gradually becoming new targets for disease diagnosis and treatment. This article briefly reviews the relationship between OPN and cardiovascular diseases in recent years.
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