An in-silico approach for discovery of microRNA-TF regulation of DISC1 interactome mediating neuronal migration

a DISC1 interactome that regulates neuronal migration through eight functional modules; b Method followed for generating the interactome. DISC1 interacts with 18 proteins forming eight functional modules (FM) that mediate neuronal migration. FM1 mediates radial migration of immature neurons, FM2 mediates radial migration of basal progenitors, FM3 mediates radial migration of newborn neurons, FM4 mediates radial migration of neuronal precursor cells, FM5 mediates radial migration of apical and basal progenitors, FM6 mediates tangential migration of cortical interneurons, FM7 mediates cranial neural crest cell migration and FM8 mediates migration of adult hippocampal progenitor